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Pramlintide, a short-acting amylin analog, has been used in diabetes treatment to smooth post-meal glucose excursions, albeit with modest weight loss

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In patients progressing from NASH to liver fibrosis, an increase in secondary bile acid (e.g., DCA) generation is observed alongside a decrease in anti-inflammatory tryptophan metabolites (e.g., IPA) and an increase in pro-fibrotic metabolites (e.g., 2-OG)

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