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FY: Writing review and editing, Investigation, Methodology, Visualization, Formal Analysis, Writing original draft

We conducted the assay by mixing the S835A mutant of NS1-5, fused with an AGIA tag at the N-terminus (substrate, Fig

& Vendemiale, G

Future treatments should focus on pathway selectivity, possibly by aiming at upstream regulators, particular lysosomal channels like TPC2 in astrocytes, or distinct cargo receptors, that are unique to astrocytes or microglia, to distinguish between beneficial metabolic support and detrimental inflammatory activation

Metabolomics, modelling and machine learning in systems biology: Towards an understanding of the languages of cells