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doi: 10.1016/j.bjid.2016.09.002

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GSHGSSG redox cycle The reversible conversion between glutathione (GSH) and its oxidized form, glutathione disulfide (GSSG), constitutes one of the most core cellular redox buffering systems

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In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage (Smeyne and Smeyne, 2013)

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