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Diabetes Res Clin Pract 115:3946 Karamali M, Heidarzadeh Z, Seifati SM, Samimi M, Tabassi Z, Hajijafari M, Asemi Z, Esmaillzadeh A (2015) Zinc supplementation and the effects on metabolic status in gestational diabetes: a randomized, double-blind, placebo-controlled trial

56-58 While several factors, including exposure to environmental toxins, 56,59,60 also contribute to mitochondrial dysfunction in the substantia nigra , age-related mutations in mitochondrial DNA are thought to be a primary culprit