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These results indicate that B12 deficiency affects the levels of the cytokines in AT and circulation, thus inducing pro-inflammatory factors which could contribute to adipose dysfunction

Notably, 2HG is a well-documented oncometabolite that exists as two enantiomers ( D and L forms) and is widely reported in many cancers ( D -2HG

A practical framework for using fasting as a strategy to improve body composition [52:15]

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People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms