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If pregnant, breastfeeding, or planning to become pregnant, consult your physician before use

Maternal nutrition can modulate gene expression through epigenetic mechanisms, methyl-donor micronutrients of one-carbon metabolism (folic acid, choline, and vitamins B6 and B12) are essential in many physiological pathways and processes, including DNA methylation (46)

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When B12 levels are low, these signals slow down, affecting concentration, focus, and memory

Here, we could show that a zonulin-dependent transmigration of immune cells from the gut into the joints occurs during the onset of arthritis