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In a few studies, the oral form has also effectively reduced dark spots and achieved skin lightening

Wu Q-Y, Wong ZC-F, Wang C, Fung AH-Y, Wong EO-Y, Chan GK-L, Dong TT-X, Chen Y, Tsim KW-K (2019) Isoorientin derived from Gentiana veitchiorum Hemsl

Intestinal dybiosis has also been shown to affect bone density [8, 104, 133135]

When in doubt, I recommend asking your provider what fillers they plan to use during your consultation and whyparticularly if you have never had filler injected before

In particular, these effects all appeared in conjunction with BPC 157 application