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Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock

l-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods

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Red meat ingestion reduced fractional renal excretion of TMAO, but increased fractional renal excretion of carnitine and two additional gut microbiota-generated metabolites of carnitine: c-butyrobetaine, and crotonobetaine