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25 A larger, double-blind RCT of 243 cancer patients receiving cisplatin or oxaliplatin and diagnosed with CIPN showed no significant difference in peripheral neuropathic symptoms between oral ALA 600 mg/day orally and placebo but further studies are needed to conclusively determine if ALA could benefit this subset of patients

Opiorphin demonstrated an increase of up to 87% in certain studies

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Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ: Assessing the quality of reports of randomized clinical trials: is blinding necessary

2.2.4 Trigger day We monitored the ovarian follicle developmental progress using vaginal ultrasound scanning and estradiol levels during treatment