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Without adequate levels of CoQ10, the electron transport chain cannot function efficiently, leading to a direct and immediate bottleneck in cellular energy production that manifests as profound systemic fatigue

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however, more studies are required to define the optimum dose and period of intervention

In vivo studies demonstrate that L-PC was able to significantly lower blood pressure in CyA treated animals and to prevent decrease creatinine clearance that normally results from CyA administration [57]