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Description
Growth hormone pathway activation (via GH peptides) increases IGF-1 stimulating chondrocyte matrix synthesis
These effects were abolished when GPR109A was knocked down using siRNA, confirming the receptors role (62)
GSH synthesis was assessed by measuring -glutamylcysteine ligase (GCL) activity in lung and liver tissue
These results are in line with at least two previous studies
Why it shows up in musculoskeletal outcomes When immune signaling stays elevated, connective tissue remodeling becomes less efficient
