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Keeping heart homeostasis in check through the balance of iron metabolism

doi: 10.3892/mmr.2012.763

Cysteine contains sulfur, which is why scientists have labeled this amino acid as the limiting factor when it comes to glutathione synthesis

Igartua DE, Martinez CS, Temprana CF, Alonso SDV, Prieto MJ (2018) PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: a biophysical and nanotoxicological characterization

In line with this finding, Erastin significantly reduced GSH-related metabolites (Cysteine, Cys-Gly, GSSG) but increased glutamine uptake in LDHB KD A549 cells ( Figure 4c, Supplementary Figure 8a, b, ), suggesting that combined inhibition of LDHB and SLC7A11 increased glutaminolysis
