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Inflammatory disorders: In rheumatoid arthritis, synovial fluid shows markedly elevated PGE2 (from COX-2 in synovial fibroblasts and infiltrating macrophages) and LTB4 (from 5-LOX in neutrophils)

doi: 10.1016/j.tiv.2020.104775 [DOI] [PubMed] [Google Scholar] 113.Kung F-P, Lim Y-P, Chao W-Y, et al

Rasmussen MH, Hvidberg A, Juul A, Main KM, Gotfredsen A, Skakkebae NE, Hilsted J

Life-threatening serotonin syndrome in a patient with chronic heart failure and CYP2D6*1/*5

This antioxidant shift is correlated with increased Nrf2 activity and the upregulation of its downstream targets