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Various factors contribute to the beginning and development of hearing loss, including genetic mutations (Lieu et al

Our previous results showed that colorectal cancer cells expressed GSTA4 (6) and we show in the current study that inactivation of GSTA4 in HCT116 cells decreases proliferation via inhibition of PI3K/MAPK pathways, supporting the tumor promotive role of GSTA4

Building on this progress, we can envision designing editors that precisely erase lactylation marks to inactivate the OCT4 or SOX2 promoters, or rewrite methylation patterns to activate differentiation programs

372,373,374,375 More recently, variants of the AAV have been investigated for its potential use for BBB penetration

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