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Loss of primary pyruvate dehydrogenase complex enzymatic function may occur from loss of mRNA expression, subunit instability, or loss or reduction of functional activity of various primary pyruvate dehydrogenase complex-associated gene products (Table 2), which could, in part, be due to partial or complete deletion of the specific gene
Andreeff M , Weidner DA, Wang RY, Zhao S, Kuenle I, Kantarjian H, Brenner MK, Goodell MA
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It has been demonstrated that high levels of UVB exposure can trigger inflammation and induce cell death in human keratinocytes through ferroptosis, which can be inhibited by the compound fer-1 [191]
The latter was already observed within 3 days of treatment
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