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Interestingly, ASCL1 is broadly distributed and has a distinct preference for oleate and linoleate, 390 suggesting that it may be a candidate to regulate the intercellular phospholipid distribution of some octadecanoids

This is supported by the fact that reactivation of latent pathogens increases during periods of increased immunodeficiency, which results in disease outbreaks throughout the year depending on whether they are reactivated or not, as occurs in systemic lupus erythematosus [240]

Acta 1813, 12631268

However, peripheral antagonist injections do not have consistent effects, due in part to biphasic effects at different doses (Woolverton, 1986

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