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Unlike skin, where pigment production is a constant process, hair pigmentation is closely tied to the phases of the hair growth cycle

Bonding of methyl groups to different molecules changes their function and ultimately gives them different jobs to perform in your body

DOI: 10.1016/j.jpsychires.2013.11.011 64

Chiu PR, Hu YC, Hsieh BS (2016) Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment

It is a well-established model for osteoarthritis, especially in cohorts of older age than we used here (52w) (Botter et al., 2011) and for the unhealthy loss in muscle (sarcopenia) and fat mass(Wijnhoven et al., 2005)