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Epidemiological studies have consistently identified major risk factors, including aging, tobacco use, poor oral hygiene and plaque accumulation, and uncontrolled diabetes mellitus

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Indeed, it has been hypothesized that variations in the insulinlike growth factor (IGF) pathway, specifically IGF1 and its binding protein 3 (IGFBP3), could account for the increased risk of SPCs 20

doi:10.1186/1472-6882-13-222 Muruganandan S, Gupta S, Kataria M, Lal J, Gupta P (2002) Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats

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