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Tgm2-catalyzed covalent cross-linking of IB drives NF-B nuclear translocation to promote SASP in senescent microglia
Within wound pathways, H 2 O 2 serves as a local signal for hypersensitive cell death and cell wall stiffening events, and as a mobile signal that stimulates defense-genes in adjacent cells (Orozco-Cardenas et al

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This approach collates biochemical, clinical and molecular genetic data from individual patients to provide a quantitative score, and is now included in the European Association for the Study of the Liver (EASL) clinical practice guidelines for Wilson disease

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