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In addition, comprehensive management of porphyria should also address systemic effects of porphyrin accumulation, such as mitochondrial dysfunction, neurological dysfunction, alterations in glucose, lipid metabolism, insulin resistance, hormonal fluctuations, and proteasomal and autophagic protein aggregation

doi: 10.3109/15563650.2011.609821 [PubMed] 22998987 Hodgman MJ, Garrard AR

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