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An original discovery: selenium deficiency and Keshan disease (an endemic heart disease)
Research indicates that chromodulin can activate the insulin receptor in a manner similar to insulin itself, while also enhancing the effect of circulating insulin

Chronic Candida overgrowth progressively depletes secretory IgA (sIgA), the guts primary antibody defence, creating a vicious cycle in which reduced immune surveillance allows further yeast proliferation and biofilm formation

10.1016/j.jep.2015.09.004 73

doi: 10.1007/s12011-010-8887-7