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Studies have shown that tumor necrosis factor alpha-induced protein 8-like 1 (TNFAIP8L1/TIPE1) could regulate PINK1/Parkin-mediated mitochondrial autophagy to protect renal function in DKD

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Research has shown that the combination of total salvianolic acid and anti-PD-L1 can reduce the release of inflammatory factors IL-6 and MCP-1, inhibit the expression of macrophage chemokines CXCL1, CXCL2, CXCL3, CCL2, and GM-CSF, thereby inhibiting the infiltration of M2 macrophages into tumor tissue, increasing the number of CD4 + T cells and CD8 + T cells in the spleen and lymph, and ultimately suppressing immune escape [251]