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In age-related disorders and chronic diseases including Alzheimers disease (AD), decreasing intracellular GSH levels is mainly attributed to declining GCL activity [4, 5]

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Furthermore, substance P augmented the expression of neuroprotective and anti-inflammatory genes in the ischemic brain, and induced neuronal survival in the brain penumbra

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Taken together, our results supported the hypothesis that the dysfunction of HCN1 channels can underlie neuroinflammation and resulting neuronal dysfunction

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These tumors contain a high percentage of infiltrating tumor-supporting cells with atypical proliferative and signaling capabilities associated with haploinsufficiency of neurofibromin from the germline mutation of NF1

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