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In age-related disorders and chronic diseases including Alzheimers disease (AD), decreasing intracellular GSH levels is mainly attributed to declining GCL activity [4, 5]

Furthermore, substance P augmented the expression of neuroprotective and anti-inflammatory genes in the ischemic brain, and induced neuronal survival in the brain penumbra

Taken together, our results supported the hypothesis that the dysfunction of HCN1 channels can underlie neuroinflammation and resulting neuronal dysfunction

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These tumors contain a high percentage of infiltrating tumor-supporting cells with atypical proliferative and signaling capabilities associated with haploinsufficiency of neurofibromin from the germline mutation of NF1
