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Likewise, fully maintained spatial learning and memory of the rats in the Morris water maze test was ascribed to hippocampal synaptic plasticity and NMDA receptor function [237] involving the entorhinal and perirhinal cortices, the prefrontal cortex, the cingulate cortex, the neostriatum, and perhaps even the cerebellum in a more limited way [237]

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Genome-wide methylation profiling of melanoma tissues and cell lines has demonstrated that the RIPK3 promoter region exhibits significantly higher CpG island hypermethylation in metastatic melanoma compared to primary lesions and normal melanocytes, a change that directly correlates with reduced RIPK3 mRNA and protein expression (99)