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When mechanical forces are applied to the ACL, integrins transmit signals into the cell, leading to changes in gene expression and protein synthesis

doi: 10.1038/s41590-021-01065-2 123

The Asia-Pacific region maintains its position as the largest consumer market, accounting for over 65% of global demand, followed by North America and the Middle East

Dysfunction of cystinosin results in the intralysosomal accumulation of the disulfide cystine, which crystallizes in some tissues and damages many parenchymal organs

This population was initially observed in a typical NG2-CreERT2 knock-in mouse model (Wang et al., 2019), where Cre activity was activated at the embryonic stage, resulting in persistent NG2 + signaling after birth (Fig