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Zhongguo Zhong Xi Yi Jie He Za Zhi
Binding to the EPORCD131 receptor complex, ARA-290 activates signaling cascades (e.g., JAK/STAT, PI3K/Akt) associated with cell survival, reduced apoptosis, and decreased pro-inflammatory cytokine production
They can regulate renin synthesis via GPR-related pathways, and a hypotensive effect by SCAFs has been described in mice
Am J Hematol 96:E38E40
The less tyrosinase is active, the less melanin is produced
