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In cases such as Friedreich's ataxia (FRDA), which is characterized by mitochondrial dysfunction, drug conjugated NPs can be combined with gene therapy for enhancing the delivery of genetic material to the target cells

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As experimental evidence, GFAP expression is markedly upregulated in reactive astrocytes during CNS inflammation, a characteristic feature of gliosis observed in AD, resulting in a 1.23.3-fold increase in GFAP levels (Kamphuis et al., 2014)

We also used a robust PECA procedure that implements algorithms that identifies peptide-level quantitative differences for more robust inferences regarding protein levels 76

Yu J, Hu Y, Xue M, Dun Y, Li S, Peng N, Liang Y, Zhao S (2016) Purification and identification of antioxidant peptides from enzymatic hydrolysate of Spirulina platensis