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The remaining rats in each group were sacrificed and hippocampal tissue was processed for Nissl staining (n=3/group), the ultrastructural analysis of mitochondria by transmission electron microscopy (n=3/group) or assays of mitochondrial ROS generation and the degree of mitochondrial swelling (n=4/group)

These strategies aim to address the underlying pathophysiological mechanismsmicrovascular damage, inflammation, oxidative stress, and advanced glycation end product (AGE) accumulationwhile mitigating systemic complications

One analysis used pooled data from five randomized placebo-controlled trials in which ginkgo, at 240 mg daily for 2226 weeks, was tested as a therapy for dementia

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