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These include a 3-week IN-OXT study [170], a 6-week trial comparing IN-OXT to galantamine (only galantamine treatment was associated with improved negative symptoms) [171], a longer 12-week 48 IU daily IN-OXT trial that found limited benefit of OXT on introspection and PANSS reduction of negative subscores, but no other effects on outcome measures [172,173], and an 8-month treatment with 40 IU IN-OXT daily, that found no significant effects on clinical symptoms or psychosocial behavior [174]

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Consequently, SAM might serve as a sensor for the nutritional condition of the cell and epigenetically modify the expression of genes that affect hunger, glucose metabolism, and lipogenesis

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