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Experiments often involve rodent or cell-based systems and measure metabolic flux, markers in adipose and muscle tissues, and transcription patterns affected by NNMT activity

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Mitochondria can take up pineal-derived or exogenously administered melatonin from the circulation, but they also have the ability to intrinsically produce it ( It is believed that the transfer of information between cells can be mediated by the mitochondrial genome transfer and even the entire mitochondria ( Figure 2 summarizes some of the many molecular processes regulated by melatonin and exosomes in various pathological conditions

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