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Both male and female transgenic mice treated with intranasal GHK-Cu had higher alternation percentages in the Y maze, indicating improved cognitive performance, beginning as early as the second month of treatment, and continuing through the third month when the study ended, compared to transgenic mice treated with intranasal saline (Figure 1A and B)

The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18

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