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Samples were diluted 1:1 with Milli-Q water for tandem mass spectrometry coupled to high-performance liquid chromatography (HPLC-MS/MS) or diluted 1:10 with FIA mobile phase additive (provided by the kit) for flow injection analysis (FIA) coupled to MS/MS

All patients have identical injections or tablets, so they can't tell which treatment they are having

Stabilizing biocatalysts

This results from depleted melanocyte reserves, leading to gray hair

Interestingly, when growing in proline medium, in which the gdh3/gdh3 mutant cells failed to undergo morphogenesis, they exhibited an overall reduction in extracellular metabolite levels when compared to the wild-type, with the exception of nicotinate, malate, and succinate levels