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Brain tissue contains the second-highest percentage of fat after adipose tissue, and fat makes up half of the brains dry weight (88)

The accumulation of misfolded or unfolded proteins leads to ER stress and the activation of the unfolded protein response (UPR), which mainly relies on three transmembrane ER stress sensors, inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating transcription factor (ATF6), to restore homeostasis [40]

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doi: 10.1007/s43032-021-00506-5

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