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Emerging evidence suggests that mitochondrial impairments may also potentiate insulin resistance development ( 2 Insulin signalling pathway Insulin regulates many pathways at molecular levels such as lipid synthesis and storage (liver and adipose tissue), stimulation of protein synthesis (in skeletal muscle and liver), inhibition of ketogenesis and gluconeogenesis (liver), and stimulation of glycolysis and glucose storage (skeletal muscle and liver) ( The insulin receptor is a heterotetrametric transmembrane glycoprotein that is composed of 22 and is a tyrosine kinase receptor ( 2.1 Phospho-inositol 3 kinase/protein kinase B pathway PI3K is a heterodimeric protein, which consists of two subunits