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Aihara K, Hirayama A, Tanaka N et al: Hydrodistension under local anesthesia for patients with suspected painful bladder syndrome/interstitial cystitis: Safety, diagnostic potential and therapeutic efficacy

Because some researchers may not have tested the mechanisms by which drugs modulate synaptic plasticity in relation to neurexins, and some drugs with potential for sustained antidepressant effect based on the modulation of synaptic plasticity by neurexins may have been overlooked

Potential Side Effects and Limited Human Data While preclinical studies have not shown significant toxicity at standard doses, the research in humans is still in its early stages

Nicholson JK, Holmes E, Kinross J, et al

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