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Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss

Histones are acetylated in transcriptionally active chromatin and hypoacetylated in inactive chromatin

doi: 10.2147/COPD.S366126 20 RanNPangZGuYPanHZuoXGuanXet al

Head Neck 38 Suppl 1:E1962-8, 2016
