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As a result, most available mitochondrial-modulating compounds are low-potency over-the-counter supplements with inexact mechanisms of action

Gut inflammasome activation shows close NAFLD association (93), and combined L-carnitine and vitamin E supplementation upregulated gut inflammasome-related genes while ameliorating liver inflammation and fibrosis in a NASH mouse model (94)

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Total and free carnitine levels could be obtained prior to the initiation of carnitine supplementation and then subsequently at 6 months and 12 months to determine the impact of duration of carnitine supplementation on effect