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The presence of fibrosis was negatively associated with SOCS3 gene promoter methylation and positively associated with mRNA expression of SOCS3, TXNIP, IL-6, and MCP-1, which are involved in oxidative stress, inflammation, and fibrogenesis [335]

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Occasional reports of acquired 5-oxoprolinemia and 5-oxoprolinuria have attributed the disorder to the administration of several drugs other than acetaminophen

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