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As expected in Figure S20, our results showed a modest induction of cell death in normal cells, indicating a favorable safety profile for the targeting drug with minimal impact on healthy cells
& Faulkner, J
Wamble, J.A
Cancer 107(5):967-74, 2006
Using mice, we then show that reducing Bdnf levels ( Bdnf +/ ) leads to upregulated sequestosome-1/p62, a key autophagy-associated adaptor protein, whose levels are inversely correlated with autophagic activity
