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Although the overall number of CD4+ T cells can initially regenerate, different subsets of CD4+ T cells (i.e., Th1, Th2, Th17, Treg, etc.) are disproportionately depleted and never return to homeostatic levels [12]

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Given these features, it can be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP), and in fact, up to 60% of POEMS patients may be initially misdiagnosed with CIDP and receive CIDP-directed treatment [11]