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Compared to conventional specific pathogen-free (SPF) mice, adult germ-free (GF) mice demonstrate reduced anxiety-like behavior in the elevated plus maze, exhibit elevated expression of brain-derived neurotrophic factor (BDNF), and show decreased expression of serotonin (5-hydroxytryptamine) receptors in the brain (Neufeld et al., 2011b

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The measurement data are expressed as mean standard deviation (SD)

Other Supporting Evidence Season of birth matters: Studies show increased autism risk in babies conceived during winter (less sun), and lowest in those conceived during summer