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The results confirmed that Tbx1 +/ and Df1 / + brains have increased concentrations of MMA compared with WT controls (all animals were PBS-treated), and they showed that although vB12 treatment had no impact on MMA in WT animals, it was restored to WT levels in both of these mutants (Fig 3)

For the pressure recordings in the superior sagittal sinus, portal vein, vena cava, and abdominal aorta (throughout 5 min), medication (10 g/kg BPC 157, 10 ng/kg BPC 157 or 5 mL/kg saline) (i) intraperitoneally or (ii) intragastrically or (iii) topically at the swollen brain through an additional midline burr hole