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Cells sense alterations in ECM stiffness and activate mechano-transductive pathwaysRhoA/ROCK, FAK/Src, and YAP/TAZleading to nuclear translocation of YAP/TAZ, enhanced transcriptional activity, and promotion of the EMT program (Figure 3, which highlights the key mechanotransductive pathways and the self-reinforcing feedback loop

McCall, M

[DOI] [PubMed] [Google Scholar] 181.Miller E.R., Pastor-Barriuso R., Dalal D., Riemersma R.A., Appel L.J., Guallar E

Because intracellular free Zn is toxic to the cell, under normal conditions, it is mostly bound to proteins such as metallothioneins (MTs), whose expression is induced by increased intracellular Zn [330]
