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Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy

Hyaluronidase is more elevated in human brain metastases than in primary brain tumours

The literature indicates that MM may stimulate lipolysis in adipocytes through the activation of specific pathways

An overload of iron in mitochondria stimulates the production of reactive oxygen species (ROS) via Fenton reactions, resulting in oxidative damage to mitochondrial DNA, proteins, and lipids

The vulnerability of mtDNA to insult, coupled with its bacterial-like molecular patterns, makes it a central actor in the cycle of metabolic failure and immune dysfunction that characterizes HIV infection