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I havent had time to read it all completely but the conclusion was that they dont really know much about it
They can also be created by environmental factors such as X-rays, ozone, tobacco smoke, and air pollution

Sabin MA, Russo VC, Azar WJ, Yau SW, Kiess W, Werther GA

The cross-sectional design limits the ability to establish causality between sagittal alignment, endplate injury, and disc degeneration
