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Previously, TMA and TMNO were considered non-toxic substances, but recently they have been considered potentially carcinogenic agents because of possible transformation to N-nitrosodimethylamine (NDMA)

Eugenol has been shown to downregulate PGC-1 expression and reduce mitochondrial membrane potential in AML cells, inhibiting their growth and promoting apoptosis through the mitochondrial pathway in AML patients [147]

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