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Glutamine-derived aspartate is translocated to the cytoplasm, subsequently, oxaloacetate is converted to malate and pyruvate, increasing the NADPH/NADP (+) ratio and thus maintaining the redox state of pancreatic cancer cells, which makes KRAS-mutated pancreatic cancer cells dependent on this pathway (Son et al., 2013)
Do not await results of assays for acetaminophen level before initiating treatment with acetylcysteine
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Development, optimization and in vitro evaluation of norcantharidin loadedself-nanoemulsifying drug delivery systems (NCTD-SNEDDS)
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