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We evaluated the lipoylation status of the E2 component of the pyruvate dehydrogenase complex (PDH-E2) and dihydrolipoamide S-succinyltransferase (DLST) as surrogate markers for LIAS activity and found no change in protein lipoylation with respect to cysteine availability (Fig

Dietary fiber has been shown to lower the risk for heart disease (Threapleton et al, 2013), and antioxidants in plants help to neutralize free radicals in the body, which are cancer-causing agents

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By targeting these pathways, the polyphenols mitigate oxidative damage, prevent protein misfolding, and reduce neuroinflammation, offering significant therapeutic benefits for neurodegenerative and metabolic disorders

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