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Interestingly, their effects on GH synthesis seem to be concentration-dependent, as low and high concentrations of nesfatins downregulate the expression of GH mRNA, while medium concentrations of nesfatins does not produce this effect (443)

It may be promising, but it is not yet proven.

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Interestingly, in another study, although F1 generation offspring did not develop obesity, both male and female F3 generation were obese and presented differential DNA methylation in genes associated with this comorbidity [123]

Experimental models of head injury