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Scientific justification for timing: If, in exceptional circumstances, you propose conducting SP studies after initial human trials (Phase I), you'll need a strong scientific justification to explain your rationale to regulatory bodies

However, long-term fasting is typically not the primary cause of NAFLD, and results from such models should consequently be translated with caution

Penn A, Murphy G, Barker S, Henk W, Penn L (2005) Combustion-derived ultrafine particles transport organic toxicants to target respiratory cells

Knockdown of miR-424-5p increases ferroptosis sensitivity of ovarian cancer cells by upregulating ACSL4 expression [22]

In addition, differences in vehicle use also affected the pharmacokinetic parameters, especially the absorption and bioavailability